Interactive response technology (IRT) is the system a trial uses to randomise participants, assign investigational product kits, manage site drug supply and support emergency unblinding. IWRS and IVRS are older names for the web and phone versions; RTSM is a common synonym.
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In short
Explained
At enrolment, the site requests randomisation and IRT allocates the participant to an arm according to the randomisation list or algorithm, including any stratification. At each dispensing visit it tells the site which kit number to give, without revealing what the kit contains. Behind the scenes it tracks inventory at each site, triggers resupply shipments when stock falls below thresholds, and prevents expired kits from being dispensed.
When a participant's treatment must be known urgently for safety, IRT provides controlled emergency unblinding, recording who unblinded, when and why. Because every allocation and dispensing event is recorded, it also supports drug accountability and reconciliation at the end of the study. See IMP inventory and drug accountability.
In Capture
Capture runs randomisation at enrolment and kit dispensing, inventory and shipments in the same platform as the eCRF, with one audit trail. Blinded roles see no allocation information, and emergency unblinding is controlled and logged.
Kit K-10418 · custody history
Only physically possible combinations can be saved.
Interactive response technology.
IWRS (interactive web response system) is a web-based form of IRT. IRT is the broader term, and RTSM is often used interchangeably.
Historically they came from different vendors. Unified platforms now run both, avoiding integrations and reconciling data in one audit trail.
It assigns kits by number without revealing contents to blinded users, and controls and logs any unblinding.