Template · PaediatricsUpdated September 28, 2026

Parent proxy ePRO for paediatric trials, set up the right way

Young children cannot fill in questionnaires, so parents often answer for them. That works for what a parent can see, and less well for what only the child can feel. This template separates the two.

  • Caregiver-completed forms
  • Self-report by age band
  • Observable behaviours only

Free sandbox · No credit card · 21 CFR Part 11 aligned

Caregiver diary

About your child today

How many times did your child wake during the night?

2

Did your child cough during the day?

Not at allA littleA lot

Did your child miss nursery or school today?

NoYes
Things a parent can observe

Key points

  • Observer-reported outcomes (ObsRO) ask caregivers about things they can see: coughing, waking, vomiting, missed school. They are reliable because the caregiver observes them directly.
  • Proxy reports ask a caregiver to report what the child feels, such as pain intensity or mood. Regulators treat these with caution, because a parent's estimate can differ from the child's experience.
  • Children can often self-report from around 8 years, and simple faces or pictorial scales work for younger children. Plan age bands in the protocol.
  • Many paediatric instruments have parallel child self-report and parent-proxy versions; use the version that matches the respondent.
  • In Capture an assessment can be set to be completed by a caregiver, on their own phone, in the same study as the child's own forms.

Who should answer

Observer-reported versus proxy-reported

Regulatory guidance on patient-focused drug development encourages collecting information from the patient whenever the patient can provide it, and from observers only for what they can actually observe. A parent can reliably report that their toddler woke three times, refused food or had a seizure. A parent cannot reliably report how nauseous their child felt. Questionnaires that ask parents to rate their child's feelings are proxy reports, and results are interpreted more cautiously.

The practical design rule is to phrase caregiver questions as observable events and behaviours, and to let children answer questions about feelings as soon as they are old enough. Many studies use age bands: caregiver-only below a threshold, child self-report plus caregiver report in a middle band, and child self-report above it.

Parallel versions

Instruments such as the PedsQL have child self-report forms for different age ranges and matching parent-proxy forms. If you collect both, schedule both, and analyse them separately; they answer different questions.

Who completes what, by age
Under 55 to 78 and over
Caregiver: observable events
Child: pictorial or faces scale
Child: standard self-report
Caregiver: proxy for feelings
Age bands defined in the protocol

In Capture

Caregiver and child forms in one participant record

Each assessment on the schedule records who completes it: the participant, a caregiver or site staff. Caregivers complete theirs on their own phone from a secure link, and the answers sit in the child's record, separate from the child's own reports.

  • Assessments completed by participant, caregiver or site staff.
  • Browser-based, no app for parents to install.
  • Pediatric assent template for the consent side.
Pediatric assent template
PRO

Patient-reported

Participant, own phone

ObsRO

Observer-reported

Caregiver

ClinRO

Clinician-reported

Site staff, clinic tablet

PerfO

Performance outcome

Site-run test, e.g. chair rise

Set up a caregiver diary

Build it in the sandbox and complete it as a parent would.

Build your paediatric ePRO free

In practice

Practical rules for caregiver-reported data

Decide who the caregiver is and keep it consistent. If a mother completes the diary for the first month and a grandparent for the second, changes in scores may reflect the reporter, not the child. Record who completed each entry, and ask families to keep the same reporter wherever possible.

Keep burden realistic. Parents of children in paediatric trials, particularly in rare diseases, already carry a heavy care load. Short daily diaries with clear windows and a few well-chosen questions work better than long weekly questionnaires. And connect consent and assent to what the family will be asked to do: the pediatric assent template covers both the parent's permission and the child's agreement.

Interpretation

When parents and children disagree

Research on paediatric quality of life consistently finds that parents and children agree more on observable domains, such as physical function and school attendance, than on internal ones, such as pain, worry and mood. Parents of children with chronic conditions also tend to rate their child's quality of life lower than the children rate it themselves.

Neither report is simply "right". Where both are collected, analyse them as separate perspectives, pre-specify which is primary, and avoid substituting a parent's answer for a missing child's answer in the same analysis. Recording who completed each questionnaire, as the child's own report or as proxy, is what makes that separation possible.

Before go-live

Paediatric ePRO checklist

Age bands defined

Who reports what at each age.

Observable wording

Caregiver items phrased as events and behaviours.

Reporter recorded

Which caregiver completed each entry.

Parallel versions scheduled

Child and parent versions where both are used.

Burden reviewed

Minutes per day for families.

Assent planned

Age-appropriate assent alongside parent permission.

FAQ

Questions about this template

Something not covered here? Ask us directly.

Can a parent answer for a child who is too unwell?

Only if the protocol allows it and the parent version of the instrument is used. Record who completed it so proxy and self-reports stay separate.

Should parent and child answers be combined?

No. Analyse them as separate perspectives, with one pre-specified as primary.

What is a parent proxy report?

A questionnaire where a parent answers on behalf of a child, including about the child's feelings. Regulators interpret proxy reports of feelings cautiously.

What is an observer-reported outcome?

An assessment where a caregiver reports observable events or behaviours, such as coughing or waking at night.

From what age can children self-report?

Often from around 8 years with standard questionnaires, and younger with pictorial scales. The protocol should define age bands.

Can caregivers complete forms at home?

Yes. Assessments can be set to be completed by a caregiver on their own phone.

Is the template free?

Yes, in the free sandbox.

Paediatric outcomes from the right person

Caregiver and child forms in one study. Free sandbox.

Build your paediatric ePRO free