Research type · NutritionUpdated September 28, 2026

Clinical trial software for nutrition research

Diet trials depend on what participants eat when nobody is watching. Capture puts meal diaries and adherence questions on participants' phones, calculates anthropometrics at entry, and keeps biomarkers, glucose data and questionnaires on one schedule, including crossover designs with washouts.

  • Meal diaries in the phone browser
  • BMI and waist-hip ratio calculated
  • Crossover schedules

Free sandbox · No credit card · 21 CFR Part 11 aligned

Meal diary

Day 9 · Intervention period 1

Which meal is this?

BreakfastLunchDinnerSnack

Time you started eating

12:40

Did you eat the study meal as provided?

All of itMostSomeNone

Anything else eaten or drunk?

Black coffee
Logged within the meal window

What matters in nutrition trials

  • Adherence is the hardest measurement. Food records, 24-hour recalls and adherence questions each have trade-offs; most trials combine a self-report with an objective marker where one exists.
  • Blinding is often impossible for whole-diet interventions, so objective outcomes (glucose, lipids, body composition, biomarkers) carry extra weight.
  • Crossover designs with washout periods are common, because between-person variation in diet response is large.
  • Anthropometrics such as BMI and waist-hip ratio are calculated automatically in Capture, so they never disagree with measured values.
  • Supplement and functional food studies that support health claims need the same data quality as drug trials; see EDC for nutraceutical clinical trials.

Dietary assessment

Capturing what people eat, without drowning them in forms

Nutrition research has three classic tools for measuring intake: prospective food records or diaries, 24-hour recalls, and food frequency questionnaires. Each trades burden against accuracy. Detailed weighed records are accurate but demanding, and people change how they eat when they have to record it. Frequency questionnaires are easy but blunt. Most intervention trials need something simpler than full dietary assessment: evidence that participants followed the intervention, plus enough about background diet to interpret the results.

Short, structured meal or adherence diaries on participants' phones fit that need well. Asked at the right time (shortly after meals, or each evening) and kept brief, they get completed. Detailed intake can then be collected at a few time points with a specialised dietary assessment tool if the protocol requires it.

Adherence, objectively

Where possible, pair self-reported adherence with an objective marker: returned supplement counts, a nutrient biomarker in blood or urine, or glucose response for a carbohydrate intervention. Record each on its own form so the analysis can compare them.

Glucose and continuous monitoring

Precision nutrition studies often use continuous glucose monitors to measure responses to meals. Raw traces usually stay in the device platform; the eCRF captures the summary metrics and meal timings needed to link glucose responses to what was eaten. Meal time fields in the diary make that link possible. See EDC for metabolic studies for related designs.

Diet adherence · Period 1

Participants

32

Meals logged

91%

Off-protocol meals

6%

Breakfast logged30/32
Lunch logged29/32
Dinner logged27/32

Evening entries drop at weekends

Adherence visible while the period is running

Crossover designs

Periods, washouts and sequences on one schedule

Crossover trials compare interventions within the same participant, separated by washout periods. Capture's study design handles arms and epochs, and randomisation allocates each participant's sequence at enrolment, with visits and windows laid out across periods and washouts.

  • Arms and epochs for periods and washouts.
  • Sequences such as AB and BA allocated as randomisation arms at enrolment.
  • Visit windows and reminders applied the same way in every period.
Clinical trial randomization software
Crossover design · 2 periods
123456789101112

Weeks

Run-in
Period 1: diet A or B
Washout
Period 2: crossover
Follow-up

Measurements

Anthropometrics calculated, labs ranged

Weight, height, waist and hip circumference are entered once and BMI and waist-hip ratio appear read-only. Blood lipids, glucose and nutrient biomarkers use lab forms with reference ranges by sex and age, and out-of-range values are flagged at entry.

  • BMI and waist-hip ratio calculated at entry.
  • Lab ranges per laboratory, by sex and age.
  • Out-of-range values flagged, never refused.
Lab data and reference ranges
Calculated field

BMI (Body Mass Index)

Auto-derived

Height (cm)

172

Weight (kg)

68.5

Result

23.2 kg/m²

Reference: WHO · shown read-only during data entry

AnthropometryBMIBSA (Mosteller)BSA (Du Bois)Waist-hip ratio
VitalsMAPPulse pressure
RenaleGFR (CKD-EPI 2021)CrCl (Cockcroft-Gault)
CardiacQTc (Bazett)QTc (Fridericia)QTcF from heart rate
DatesAge from DOBMinutes betweenHours between

Set up a meal diary and a crossover schedule

Build both in the free sandbox and try the diary on your phone.

Build your nutrition study free

Supplements and foods

Blinding, placebos and compliance in supplement and food studies

Studies of supplements and functional foods can often be blinded where whole-diet studies cannot, but only if the placebo is well matched in appearance, taste and packaging. Record the product batch dispensed to each participant, and ask participants at the end which product they think they received: a simple blinding assessment that reviewers find reassuring.

Compliance is usually measured by counting returned capsules or sachets at each visit and comparing with the number expected. Record dispensed and returned counts as numbers, so compliance percentages are calculated consistently rather than estimated by the site. For studies intended to support health claims, design endpoints and populations with the relevant regulator's expectations in mind from the start; see EDC for supplement clinical trials.

Background diet and confounders

Participants' usual diets vary, and changes in background diet during a study can swamp the effect of a supplement. Ask participants to keep their usual diet, capture it briefly at baseline and at the end, and record major changes (such as starting a weight-loss diet) as protocol deviations if the protocol defines them.

Study build

Nutrition trial build checklist

Adherence measure defined

Self-report plus an objective marker where one exists.

Diary burden kept low

Short, structured questions at the right time rather than full intake records every day.

Background diet captured

At baseline and key time points, with a validated method if the analysis needs it.

Washout justified

Long enough for the outcome to return to baseline between periods.

Units fixed

Glucose, lipids and biomarkers in one unit per field.

Claims evidence planned

If results will support a health claim, design endpoints with the relevant regulator's expectations in mind.

FAQ

Questions teams ask before they switch

Something not covered here? Ask us directly.

How do nutrition trials measure what participants eat?

With food records, 24-hour recalls or food frequency questionnaires for detailed intake, and short adherence or meal diaries for intervention compliance, often paired with objective biomarkers.

Can participants log meals on their phone?

Yes. Meal and adherence diaries run in the phone browser from a secure link, with completion windows and reminders.

Does Capture support crossover trials?

Yes. Arms and epochs define periods and washouts, and randomisation allocates sequences at enrolment.

Can BMI be calculated automatically?

Yes. BMI and waist-hip ratio are built-in calculated fields shown read-only during entry.

Can CGM data be used?

Record CGM summary metrics and meal times on structured forms. Raw traces usually remain in the device platform.

Is there a free trial?

Yes. The free sandbox has every feature with no credit card.

Know what participants actually ate

Meal diaries, crossover schedules and calculated anthropometrics. Free sandbox.

Build your nutrition study free