Established EDC systems do the core job. The differences are in how studies get built and amended, what else is in the same system, and what it costs at your study size. Here is what to compare and where Capture fits.
Free sandbox · No credit card · 21 CFR Part 11 aligned
Question form
CRF or ePRO
Lab table
Analytes, units, ranges
1. Systolic blood pressure
Required · Number · mmHg · 0 dp
2. Diastolic blood pressure
Required · Number · mmHg · 0 dp
3. Pulse rate
Required · Number · beats/min
4. Body temperature
Required · Number · °C · 1 dp
5. Position during measurement
Required · Sitting, Supine, Standing
The short version
Why teams compare
Most EDC systems can capture a visit, check a value and raise a query. What varies is how quickly a study gets from protocol to live, and how painful amendments are. In vendor-built models, every form change goes through a specification and change-control cycle. In self-serve models, your team makes the change, tests it and approves it, with the audit trail recording what changed.
Capture's AI Study Generator reads the protocol and drafts the visit schedule and forms for review, and the AI form builder drafts questions or lab tables from a description or an uploaded file. Nothing is saved without human review. See the CRF builder.
Organisations running several similar studies can export a study configuration and import it into a new study, copying forms and the visit schedule as a starting point.

Criteria
| Criterion | Why it matters | Capture |
|---|---|---|
| Build ownership | Speed and cost of builds and amendments | Your team builds; AI drafts from the protocol |
| Edit checks | Clean data at entry | Range and custom-value rules with auto-queries |
| Integrated modules | Reconciliation and vendor count | EDC, ePRO, eConsent and randomisation in one study |
| Compliance controls | Part 11 and GCP expectations | Field-level audit trail, re-authenticated e-signatures, role-based access |
| Exports | Analysis and submissions | CSV and Excel with a data dictionary, raw and decoded |
| Cost | Fit for your study size | Free sandbox; pay when you go live; no per-site fee |
Data quality
Set range and custom-value edit checks yourself. When a site enters a value that breaks a rule, an auto-query is raised straight away. Approved forms are locked for live use, and every change is recorded field by field with who, when and why.
Edit checks / auto-queries
2Type
Range High
Operator
Greater than
Value
180
Priority: High
Type
Range Low
Operator
Less than
Value
80
Priority: Normal
Query raised automatically
Value 192 violates limit (180). Please verify.
Upload it to the free sandbox and compare the draft with your current system.
Switching
Switch between studies where you can. Export form specifications or annotated CRFs from the current system and use them to draft the new build, then validate the new study with your usual testing. Historical data stays in its original export and is merged at analysis if needed.
If a mid-study switch cannot be avoided, plan a cut-over date, freeze data in the old system, and document the mapping between the two. See how to switch EDC vendors mid-study and the EDC vendor comparison guide.
Evaluating a shortlist
Time it in each system.
Who does it and how long it takes.
See the query workflow.
Readable, complete, exportable.
Data dictionary and formats.
Build, licence, per-site and support.
Sponsors, CROs and academic teams comparing EDC options, including teams using or evaluating TrialMaster, who want to see a self-serve, unified option alongside it.
No. Vendors change their offerings, so we describe what to evaluate and where Capture fits. Confirm current capabilities and terms directly with TrialMaster.
Yes. The free sandbox has every feature with sample data, no credit card and no time limit.
Yes. The AI form builder drafts questions from an uploaded file or description, and the AI Study Generator drafts visits and forms from a protocol, all for your review.
Capture provides a field-level audit trail, re-authenticated electronic signatures and role-based access control. Part 11 compliance also depends on how the sponsor validates and uses the system.
Keep exploring
Capture vs TrialMaster
The head-to-head comparison.
EDC vendor comparison guide
Broader comparison.
Medidata Rave alternatives
Enterprise EDC comparison.
iMedNet EDC alternatives
Another EDC comparison.
CRF builder
AI-drafted forms.
How to switch EDC vendors
Planning a move.
21 CFR Part 11 compliant EDC
Compliance controls.
Free sandbox with every feature. No sales call.