Vendor comparison · eCOAUpdated September 29, 2026

Looking at Clario eCOA alternatives? Start with what your study needs

Large endpoint technology providers serve large global programmes well. Smaller sponsors, academic teams and CROs often want something they can build themselves, with ePRO in the same system as EDC. Here is what to compare and where Capture fits.

  • ePRO in the same audit trail as EDC
  • Self-serve build
  • Free sandbox

Free sandbox · No credit card · 21 CFR Part 11 aligned

ePRO compliance by site
Site 0194%
Site 0281%
Site 0358%

At-risk participants

03-0073 diary entries missedReminder delivered
03-011Week 4 questionnaire overdueEmail bounced

The short version

  • Clario, formed from the combination of ERT and Bioclinica, is a large endpoint technology provider known for eCOA, cardiac safety and medical imaging in large trials.
  • Teams look at alternatives when they need a faster, self-serve build, pricing that fits smaller studies, or ePRO and EDC in one system rather than two.
  • Compare the device model (BYOD or provisioned), licensed instrument handling, scheduling and reminders, integration with EDC and total cost.
  • Capture is a unified platform: ePRO, EDC, eConsent and randomisation in one study with one audit trail. It is software, not a core lab: it does not replace centralised cardiac safety or imaging services.
  • Build a real questionnaire in each shortlisted system before choosing.

Why teams compare

When a full-service eCOA model is more than you need

Full-service eCOA providers typically design, build, translate and support questionnaires for you, often on provisioned devices, which suits large global trials with many licensed instruments. For a 60-participant Phase 2 study or an academic trial, that model can mean longer timelines and costs that are hard to justify, plus a separate system to reconcile with the EDC.

A unified platform takes a different approach: your team builds the questionnaires, participants answer on their own phones, and the answers land in the same study database and audit trail as site data. See best ePRO software for a vendor-neutral guide to the categories.

Services you may still need

If your trial relies on centralised ECG reading or imaging core labs, those remain specialist services. A unified EDC and ePRO platform can hold the results you receive from them, but it is not a replacement for the reading service itself.

Evening diary

Question 3 of 8

How would you rate your fatigue today?

0 = no fatigue, 10 = worst imaginable

012345678910
Add a photo (optional)
BackNext
● Answers saved as they go

Criteria

What to compare for eCOA

CriterionWhy it mattersCapture
Device modelBYOD lowers cost and friction; provisioned devices control the environmentBrowser-based BYOD with no app; clinic devices supported
Build ownershipWho builds and amends questionnaires, and how fastYour team, in a visual builder; AI drafts from a description or file
Licensed instrumentsLicence tracking and faithful migrationLicence number, holder and expiry per form; collection blocked if lapsed
Scheduling and remindersCompliance depends on themVisit-based or recurring; reminders when due, next day and before the window closes
EDC integrationTwo systems need reconciliationePRO, EDC and eConsent in one study
Cost and set-upSmall studies cannot absorb large set-up feesFree sandbox; pay when you go live

Capture ePRO

Questionnaires on participants' phones, data in one place

Participants open a secure link on their own phone with no app to install. Diaries and questionnaires follow the schedule with windows and reminders that respect quiet hours, and compliance is visible by study, country and site, with at-risk participants flagged.

  • BYOD in the browser.
  • PROMIS short forms in the library with licence tracking.
  • Compliance and at-risk participants on the dashboard.
eCOA software for clinical trials

From: Capture.Study · Sleep and Recovery Study

Your questionnaire is ready

Hi Anna, your evening diary is open until midnight. Tap the button to start. The link signs you in, no password needed.

Open my tasks

Questions? Reply to reach your study site.

My tasks

Evening diary

Due tonight

Week 4 questionnaire

Opens Monday

+ Report an episode

Build a questionnaire and complete it on your phone

Free sandbox with every feature, no credit card.

Compare options free

Switching

Moving questionnaires between systems

Licensed instruments cannot simply be copied between systems. The licence holder usually needs to approve the electronic version, and migration from one electronic format to another may need a check that the questions look and behave the same. Plan time for that, especially for instruments with many translations.

For ongoing studies, switching mid-study is rarely worth the risk; new studies are the natural point to change. See how to switch EDC vendors mid-study for the trade-offs.

Evaluating a shortlist

eCOA evaluation checklist

Build your own questionnaire

Not a vendor-prepared demo.

Complete it on a phone

From a link, on the device participants will use.

Miss an entry

Check windows and reminders.

Check licence handling

How approvals and expiry are managed.

Export the data

Codes, labels and timestamps.

Get a full price

Set-up, per-participant, per-site and device costs.

FAQ

Questions teams ask before they switch

Something not covered here? Ask us directly.

Who is this Clario alternatives page for?

Sponsors, CROs and academic teams comparing eCOA options, including teams using or evaluating Clario, who want to see a self-serve, unified option alongside it.

Does this page compare features line by line?

No. Vendors change their offerings, so we describe what to evaluate and where Capture fits. Confirm current capabilities and terms directly with Clario.

Can I test Capture before deciding?

Yes. The free sandbox has every feature with sample data, no credit card and no time limit.

Does Capture provide cardiac safety or imaging services?

No. Capture is software for data capture, not a core lab. It can hold results you receive from specialist reading services.

Can participants use their own phones?

Yes. Questionnaires open in the phone browser from a secure link, with no app to install.

See if a unified platform fits your study

Build a questionnaire in the free sandbox today.

Compare options free